Why evaluate sudomotor function?
Sudomotor function is known to reflect sympathetic activity and to provide insight into postganglionic autonomous innervation. Its study represents a useful tool to evaluate autonomic disorders.
The need for a faster sudomotor function test
Impeto technology is a new method for sudomotor function assessment. It measures the ability of sweat glands to release chloride ions in response to electrochemical activation. [1].
Once an abnormality is suspected or confirmed, more specialized tests are recommended to diagnose the underline cause.
Evaluation of sudomotor function in diabetes
Diabetic autonomous neuropathy primarily affects the unmyelinated axons of small fiber nerve
Diabetes is one of the major cause of nerve damage. Metabolic impairment in diabetes patients and the related
inflammatory processes primarily affect the unmyelinated axons of small fiber nerves [2]. This is known as Diabetic
Autonomic Neuropathy (DAN), a subtype of peripheral neuropathies [3].
Several clinical studies are on going to test our technology for DAN detection.
[1] Hubert D, Dusser D, Bry A, Fajac I. Abnormal electrochemical skin conductance in cystic fibrosis. Journal of Cystic Fibrosis. 2011;10:15-20 [2] Poitout V, Robertson RP. Secondary ß-cell failure in type 2 diabetes – a convergence of glucotoxicity and lipotoxicity. Endocrinology 2002; 143(2):339-342 [3] Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic Autonomic Neuropathy. Diabetes Care 2003; 26:1553-1579
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