SUDOSCAN+ is a test that provides an accurate evaluation of sweat gland function. SUDOSCAN+’s focus on small nerve fibers within the peripheral nervous system innervating the sweat glands. SUDOSCAN+ measures the ability of the sweat glands to release chloride ions in response to an electrochemical stimulus on the palms of the hands and soles of the feet, areas with the highest sweat gland density.
SUDOSCAN+ test results can be used as indicators for patients at risk of autonomic dysfunction through the measurement of Electrochemical Sweat Conductance (ESC) and the amount of observed asymmetry between the right and left side.
SUDOSCAN+ has been tested for small fiber nerve neuropathies in several diseases and compared to guidelines reference tests:
> Chemotherapy induced polyneuropathy
> Familial amyloid polyneuropathy
> Fabry disease
SUDOSCAN+ assesses symmetric neuropathies
Most of diabetic neuropathies are symmetric on both limbs . One of our recent clinical study has demonstrated that SUDOSCAN+ assesses symmetric neuropathies .
SUDOSCAN+ detects peripheral neuropathy of hands and feet
- Correlation coefficient between foot ESC and VPT was -0.45 (p<0.0001) 
- Correlation coefficient between foot ESC and retinopathy status was -0.42 (p<0.0001) 
SUDOSCAN+ reflects anomalies of the sympathetic nervous system
SUDOSCAN+ detects cardiac autonomic neuropathy
Electrochemical Sweat Conductance measured by SUDOSCAN+ reflects sweat function which is sympathetic dependant.
A recent study conducted in Pune, India, has demonstrated that people with ESC<40µS (abnormal ESC) have more risk to have abnormal Ewing tests which reflects cardiac autonomic neuropathy status. 
 Boulton et al.Diabetic Somatic Neuropathy. Diabetes care. 2004;27(6):1458-1486  Gin et al. Assessment of diabetic foot risk by vibration perception threshold and a simple method measuring sudomotor function. Diabetes & Metabolism. DOI: 10.1016/j.diabet.2011.05.003  Yajnik et al. Quick and simple evaluation of sudomotor function for early detection of diabetic neuropathy. Diabetic medicine. Submitted