SUDOSCAN in asymptomatic Hepatitis C


SUDOSCAN detects small fiber neuropathy in asymptomatic hepatitis C virus-related cirrhosis patients

ES. Tharwa et al.
Article title: Sudomotor Changes in Hepatitis C Virus Infection with or without Diabetes Mellitus: A Pilot Study in Egyptian Patients. 
Am. J. Trop. Med. Hyg., 00(0), 2020, pp. 1–5.

In a study conducted by Tharwa et al from Menoufia University, Egypt, small fiber neuropathy in asymptomatic Hepatitis C virus-related cirrhotic patients with (group 1, n=49) or without diabetes mellitus (group 2, n=48) was evaluated through sweat function assessment by SUDOSCAN test.

Peripheral neuropathy was detected in none of the healthy controls, 39% of Hepatitis C virus-related cirrhotic patients without diabetes mellitus, and 62% of Hepatitis C virus -related cirrhotic patients with type 2 diabetes mellitus (P< 0.0001).

Feet electrochemical skin conductance was decreased in group 1 as compared with controls (67 ± 19 versus 88 ± 7 μS, P < 0.0001) and more severely decreased in group 2 (58 ± 19 μS, P = 0.017 as compared with group 1), see Figure 1.


 Figure 1: Box-plots of feet electrochemical skin conductance (FESC) in controls, patients with hepatitis C virus (HCV)–related cirrhosis, and patients with HCV-related cirrhosis as well as diabetes mellitus (DM).
Feet electrochemical skin conductance is decreased in HCV-related cirrhosis as compared with controls, and more profoundly decreased in patients with DM in addition.

Moreover, a significant correlation was observed between feet Electrochemical skin conductance measured with SUDOSCAN and parameters of increased portal pressure and parameters of increased severity of hepatic dysfunction, see Table 1.


Table 1: Spearman’s correlations between FESC and parameters of increased portal pressure and severity
of hepatic dysfunction

Conclusion: Electrochemical skin conductance measurement is a valuable, noninvasive method for early detection of small fiber neuropathy in asymptomatic Hepatitis C virus-related cirrhosis, with or without diabetes mellitus.

Impeto Medical

Impeto Medical


SUDOSCAN is a quick and non-invasive test that provides an accurate evaluation of sweat gland function reflecting the status of the autonomic nervous system.

With quantitative and reproducible results, SUDOSCAN allows physicians to detect early and follow-up peripheral neuropathy to monitor disease progression and assess treatment efficacy for better patient management.

SUDOSCAN efficacy has been evaluated in the assessment of small fiber neuropathies in several diseases and compared to reference tests recommended in guidelines.

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