EZSCAN principle

Small fiber neuropathy and diabetes

Several studies have proven that small fiber neuropathies are common in people with insulin resistance and prediabetes (IGT) [1] [2]. Sudomotor function is known to reflect sympathetic activity and to provide insight into postganglionic autonomic innervation. Its assessment represents a useful tool to evaluate autonomic disorders [3]. Investigation of sudomotor function can help in early detection of cardiometabolic risk.

visuels-sweat-gland-left-1
visuels-sweat-gland-right-2

Normal innervation of sweat glands in a healthy subject (left). Loss of innervation in a patient with diabetes (right).

A test of sudoral function

The degeneration of small nerve fibers reduces sweat gland innervation and impairs sudomotor function.

The technology tests sweat gland function by applying a small direct current to both hand and foot sensor plates. At a low voltage, the stratum corneum acts as a capacitor, leaving the sweat ducts as the only channel for the transmission of Cl- ions.

A quantitative measure of chloride conductance (measured in microsiemens) is provided and its results serve as a biomarker to assess sweat gland function in relation to sweat gland innervation.

visuel-a-test-of-sudoral-function-smartphone

The degeneration of small nerve fibers reduces sweat gland innervation and impairs sudomotor function.

SUDOSCAN tests sweat gland function by applying a small direct current to both hand and foot sensor plates. At a low voltage, the stratum corneum acts as a capacitor, leaving the sweat ducts as the only channel for the transmission of Cl- ions.

SUDOSCAN provides a quantitative measure of chloride conductance (measured in microsiemens) and its results serve as a biomarker to assess sweat gland function in relation to sweat gland innervation.

Visuel-ezscan-screen-results

EZSCAN result screen

A risk score according to measured conductances and patient data (hight, weight, age) is calculated:

  • Green : no risk
  • Yellow: moderate risk
  • Orange: high risk
  • Red: very high risk
Visuel-ezscan-screen-results

EZSCAN RESULT SCREEN

A risk score according to measured conductances and patient data (hight, weight, age) is calculated:

  • Green : no risk
  • Yellow: moderate risk
  • Orange: high risk
  • Red: very high risk

Impeto Medical technology principle

REFERENCES:

[1] Tavee J and Zhou L. Small fiber neuropathy : a burning problem. Cleveland clinic journal of medicine. 2009;76:297-305.
[2] Putz Z et al. Non invasive evaluation of neural impairment in subjects with impaired glucose tolerance. Diabetes care. 2009;32:181-183.
[3] Low PA. Evaluation of sudomotor function. Clinical Neurophysiology. 2004;115:1506-1513.

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