SUDOSCAN and diabetes

Frises-pictogrammes-Diabetes-09-2021

Early detection of diabetic neuropathy

SUDOSCAN efficacy in early detection of diabetic neuropathy has been demonstrated in several studies, wich helps for a better management of diabetes complications sush as diabetic foot and cardiac autonomic neuropathy and follow up disease progression.

Why control diabetic complications

Type 2 diabetes often progresses in silence, without developing clinically relevant symptoms. It frequently remains undiagnosed until complications appear. As much as one third of all cases may not be detected at all [1].

At the same time, there is epidemiologic evidence that complications are triggered in a much earlier stage of the disease than previously thought [2, 3]. For a substantial number of patients, irreversible tissue damage (peripheral vascular disease, nephropathy, retinopathy, neuropathy) have already set in at the time of diagnosis [4].

60-70% of patients with diabetes have neuropathies [5].

Diabetic Autonomic Neuropathy (DAN) is a serious and common complication of diabetes that can involve the entire autonomic nervous system. It frequently precedes other complications and manifests as dysfunctions in one or more organ systems, for example cardiovascular, gastrointestinal, genitourinary, ocular or sudomotor.

How to reduce diabetic foot risk and cardiovascular complications

Diabetic foot

Loss of autonomous innervation affects peripheral microvascular perfusion. It ultimately results in dry skin, loss of sweating and the development of fissures and cracks leading to infectious ulcers and gangrene [6]. In the long run, amputation and foot ulceration are the most common consequences of peripheral diabetic neuropathy and major causes of morbidity and disability. Every 30 seconds a lower limb is lost to diabetes somewhere in the world and up to 70 % of all leg amputations are due to the same cause. Currently available methods used to detect distal peripheral neuropathy rely on assessment of irreversible damage to the large nerve fibers. The commonly used tests (sensation (pinprick, monofilament), vibration sensation, pressure sensation) are subjective and offer poor reproducibility.

Cardiovascular complications

Cardiovascular Autonomic Neuropathy (CAN) is the clinically most critical form of diabetic autonomic neuropathy. It is caused by a loss of autonomous cardiac innervation and results in diminished Heart Rate Variability (HRV) and vascular dynamics. Detecting Cardiovascular Autonomic Neuropathy early can help prevent sudden cardiac death and myocardial infarction [6-7]. Heart Rate Variability has proven to be a predictor for all-cause mortality but is time consuming and requires specific diagnostic equipment [7].

SUDOSCAN is a quick and non-invasive test to early detect diabetic peripheral neuropathy. 

About SUDOSCAN

SUDOSCAN is a quick and non-invasive test that provides an accurate evaluation of sweat gland function reflecting the status of the autonomic nervous system. With quantitative and reproducible results, SUDOSCAN allows physicians to detect early and follow-up peripheral neuropathy to monitor disease progression and assess treatment efficacy for better patient management. SUDOSCAN efficacy has been evaluated in the assessment of small fiber neuropathies in several diseases and compared to reference tests recommended in guidelines.

References:

[1]  American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care. 2007; 30(suppl):S4-S41.
[2]  Deedwania PC, Fonseca VA. Diabetes, prediabetes and cardiovascular risk: shifting the paradigm. Am J Med. 2005; 11:939-947.
[3]  DECODE Study Group EDEG. Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovascular diseases? Diabetes Care. 2003; 26(3):688-696.
[4]  Weissmann PN. Reappraisal of the pharmacologic approach to treatment of type 2 diabetes mellitus. Am J Cardiol. 2002; 90(suppl):42G-50G.
[5]  National Diabetes Statistics fact sheet, NIIDDK, 2007.
[6]  Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic Autonomic Neuropathy. Diabetes Care 2003; 26:1553-1579.
[7]  Vinik AI, Ziegler D. Diabetic Cardiovascular Autonomic Neuropathy. Circulation 2007; 115:387-397.
[8]  Selvarajah D et al (Tesfaye S). Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention. The Lancet Diab & Endoc, Volume 7, Issue 12, December 2019, 938-948. 

SUDOSCAN BENEFITS

FAST

No patient preparation
Results in 3 minutes
Easy-to-read critical data points to help physicians reach a diagnosis

SECURE

Non-invasive
No fasting
Easy to operate
CE and FDA approvals

ACCURATE

Reproducible quantitative results
Independent from environmental conditions
Backed by evidence-based research
150 peer-reviewed journals publications

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