A clinically proven test

SUDOSCAN results compared to Skin Biopsy and QSART


SUDOSCAN effectiveness have been compared to main small fiber neuropathy assessment technics in several scientific publications. G. Smith et al [1] have demonstrated SUDOSCAN’s diagnostic performance was comparable to Intraepidermal Nerve Fiber Density (IENFD) and QSART in detecting Neuropathy. 

IENFD distal leg and foot QSART sweat volumes had similar area under the curve (AUC) to SUDOSCAN values (ESC). 


IENFD: lntraepidermal Nerve Fiber Density from a skin biopsy
QSART: Quantitative Sudomotor Axon Reflex Testing- sudomotor function testing

Reference values assessed in large adult population

A large adult population have been tested for neuropathy with SUDOCAN [2]. Thereby reference values have been determined with three levels: Electrochemical skin conductance (ESC) zones for normal sudomotor function (green), moderate sudomotor dysfunction (yellow) and severe sudomotor dysfunction (red).



[1]  Smith G et al. The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy. Journal of Diabetes and its Complications. 2014;28(4):511-516.
[2]  Vinik AI, Nevoret ML, Casellini C . The New Age of Sudomotor Function Testing: A Sensitive and Specific Biomarker for Diagnosis, Estimation of Severity, Monitoring Progression, and Regression in Response to Intervention. Front Endocrinol (Lausanne). 2015 Jun 11;6:94. 

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