SUDOSCAN applications

Sudomotor dysfunction is a common finding, and one of the earliest detectable abnormalities in a number of peripheral and autonomic neuropathies.

SUDOSCAN has been tested for small fiber neuropathies in several diseases and compared to guide references tests :

  • Diabetes
  • Parkinson
  • Chemotherapy induces polyneuropathy
  • Familial amyloid polyneuropathy
  • Fabry disease

Prevent and manage diabetes complications

Diabetes is shown to be the primary cause of small fiber neuropathy. The American Diabetes Association recommends including sudomotor function assessment of small fiber in the current panel of diagnostic tests for the detection of peripheral neuropathies. Early identification of these complications, which may be asymptomatic in up to 50% of diabetes patients, has the potential to reduce or delay their complications with timely preventative treatment.

SUDOSCAN has shown to be a sensitive tool to detect neuropathy in patients with DM.
NIS-LL: Neuropathy Impairment Score within the Lower Limbs DM: Diabetes Mellitus ESC: Electrochemical Sweat Conductance (SUDOSCAN)
NIS-LL: Neuropathy Impairment Score within the Lower Limbs
DM: Diabetes Mellitus
ESC: Electrochemical Sweat Conductance (SUDOSCAN)

SUDOSCAN has also shown to be a good tool to evaluate the treatment efficacy.

Winiecki

Cardiovascular  autonomic  neuropathy  (CAN)  is  a  common  but  often  overlooked  complication  of  diabetes. Studies have shown that SUDOSCAN my may be used for early screening of CAN in everyday  clinical  practice  before  resorting  to  the  more  sophisticated  and  specific,  but  ultimately  more  time-consuming,  Ewing  tests.

Detect early and follow-up of small fiber peripheral neuropathy in neurological diseases

Patients with neuropathy had significantly lower ESC scores than healthy controls

ESC: Electrochemical Sweat Conductance

SUDOSCAN has shown to had a diagnostic performance similar to accepted diagnostic tools for small fiber neuropathy (IENFD and QSART).

IENFD: Intraepidermal Nerve Fiber Density from a skin biopsy QSART: Quantitative Sudomotor Axon Reflex Testing – sudomotor function testing
IENFD: Intraepidermal Nerve Fiber Density from a skin biopsy
QSART: Quantitative Sudomotor Axon Reflex Testing – sudomotor function testing

New drug development

SUDOSCAN is involved in the European project e-PREDICE (Early PRevention of DIabetes Complications in people with hyperglycaemia in Europe). e-PREDICE aims at testing the long term efficacy of different therapeutic schemes for the early prevention of diabetic complications in people with hyperglycaemia currently under lifestyle intervention.

This project involving 15 centers in Europe was developed in cooperation with Pr. Jaakko Tuomilehto.

Contact Impeto Medical if you have a drug development project.

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