Sudomotor dysfunction is a common finding, and one of the earliest detectable abnormalities in a number of peripheral and autonomic neuropathies.
SUDOSCAN has been tested for small fiber neuropathies in several diseases and compared to guide references tests :
- Chemotherapy induces polyneuropathy
- Familial amyloid polyneuropathy
- Fabry disease
Prevent and manage diabetes complications
Diabetes is shown to be the primary cause of small fiber neuropathy. The American Diabetes Association recommends including sudomotor function assessment of small fiber in the current panel of diagnostic tests for the detection of peripheral neuropathies. Early identification of these complications, which may be asymptomatic in up to 50% of diabetes patients, has the potential to reduce or delay their complications with timely preventative treatment.
SUDOSCAN has also shown to be a good tool to evaluate the treatment efficacy.
Cardiovascular autonomic neuropathy (CAN) is a common but often overlooked complication of diabetes. Studies have shown that SUDOSCAN my may be used for early screening of CAN in everyday clinical practice before resorting to the more sophisticated and speciﬁc, but ultimately more time-consuming, Ewing tests.
Detect early and follow-up of small fiber peripheral neuropathy in neurological diseases
Patients with neuropathy had significantly lower ESC scores than healthy controls
SUDOSCAN has shown to had a diagnostic performance similar to accepted diagnostic tools for small fiber neuropathy (IENFD and QSART).
New drug development
SUDOSCAN is involved in the European project e-PREDICE (Early PRevention of DIabetes Complications in people with hyperglycaemia in Europe). e-PREDICE aims at testing the long term efficacy of different therapeutic schemes for the early prevention of diabetic complications in people with hyperglycaemia currently under lifestyle intervention.
This project involving 15 centers in Europe was developed in cooperation with Pr. Jaakko Tuomilehto.
Contact Impeto Medical if you have a drug development project.